Showing posts with label Health. Show all posts
Showing posts with label Health. Show all posts

Flu? Malaria? Disease forecasters look to the sky






NEW YORK (AP) — Only a 10 percent chance of showers today, but a 70 percent chance of flu next month.


That’s the kind of forecasting health scientists are trying to move toward, as they increasingly include weather data in their attempts to predict disease outbreaks.






In one recent study, two scientists reported they could predict — more than seven weeks in advance — when flu season was going to peak in New York City. Theirs was just the latest in a growing wave of computer models that factor in rainfall, temperature or other weather conditions to forecast disease.


Health officials are excited by this kind of work and the idea that it could be used to fine-tune vaccination campaigns or other disease prevention efforts.


At the same time, experts note that outbreaks are influenced as much, or more, by human behavior and other factors as by the weather. Some argue weather-based outbreak predictions still have a long way to go. And when government health officials warned in early December that flu season seemed to be off to an early start, they said there was no evidence it was driven by the weather.


This disease-forecasting concept is not new: Scientists have been working on mathematical models to predict outbreaks for decades and have long factored in the weather. They have known, for example, that temperature and rainfall affect the breeding of mosquitoes that carry malaria, West Nile virus and other dangerous diseases.


Recent improvements in weather-tracking have helped, including satellite technology and more sophisticated computer data processing.


As a result, “in the last five years or so, there’s been quite an improvement and acceleration” in weather-focused disease modeling, said Ira Longini, a University of Florida biostatistician who’s worked on outbreak prediction projects.


Some models have been labeled successes.


In the United States, researchers at Johns Hopkins University and the University of New Mexico tried to predict outbreaks of hantavirus in the late 1990s. They used rain and snow data and other information to study patterns of plant growth that attract rodents. People catch the disease from the droppings of infected rodents.


“We predicted what would happen later that year,” said Gregory Glass, a Johns Hopkins researcher who worked on the project.


More recently, in east Africa, satellites have been used to predict rainfall by measuring sea-surface temperatures and cloud density. That’s been used to generate “risk maps” for Rift Valley fever — a virus that spreads from animals to people and in severe cases can cause blindness or death. Researchers have said the system in some cases has given two to six weeks advance warning.


Last year, other researchers using satellite data in east Africa said they found that a small change in average temperature was a warning sign cholera cases would double within four months.


“We are getting very close to developing a viable forecasting system” against cholera that can help health officials in African countries ramp up emergency vaccinations and other efforts, said a statement by one of the authors, Rita Reyburn of the International Vaccine Institute in Seoul, South Korea.


Some diseases are hard to forecast, such as West Nile virus. Last year, the U.S. suffered one of its worst years since the virus arrived in 1999. There were more than 2,600 serious illnesses and nearly 240 deaths.


Officials said the mild winter, early spring and very hot summer helped spur mosquito breeding and the spread of the virus. But the danger wasn’t spread uniformly. In Texas, the Dallas area was particularly hard-hit, while other places, including some with similar weather patterns and the same type of mosquitoes, were not as affected.


“Why Dallas, and not areas with similar ecological conditions? We don’t really know,” said Roger Nasci of the Centers for Disease Control and Prevention. He is chief of the CDC branch that tracks insect-borne viruses.


Some think flu lends itself to outbreak forecasting — there’s already a predictability to the annual winter flu season. But that’s been tricky, too.


Seasonal flu reports come from doctors’ offices, but those show the disease when it’s already spreading. Some researchers have studied tweets on Twitter and searches on Google, but their work has offered a jump of only a week or two on traditional methods.


In the study of New York City flu cases published last month in the Proceedings of the National Academy of Sciences, the authors said they could forecast, by up to seven weeks, the peak of flu season.


They designed a model based on weather and flu data from past years, 2003-09. In part, their design was based on earlier studies that found flu virus spreads better when the air is dry and turns colder. They made calculations based on humidity readings and on Google Flu Trends, which tracks how many people are searching each day for information on flu-related topics (often because they’re beginning to feel ill).


Using that model, they hope to try real-time predictions as early as next year, said Jeffrey Shaman of Columbia University, who led the work.


“It’s certainly exciting,” said Lyn Finelli, the CDC’s flu surveillance chief. She said the CDC supports Shaman’s work, but agency officials are eager to see follow-up studies showing the model can predict flu trends in places different from New York, like Miami.


Despite the optimism by some, Dr. Edward Ryan, a Harvard University professor of immunology and infectious diseases, is cautious about weather-based prediction models. “I’m not sure any of them are ready for prime time,” he said.


Health News Headlines – Yahoo! News





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Biogen says Lou Gehrig’s disease drug fails in trial






(Reuters) – An experimental drug to combat amyotrophic lateral sclerosis, commonly called Lou Gehrig‘s disease in the United States, failed to work in an important trial and Biogen Idec said it would stop development of the treatment.


The drug, dexpramipexole, had shown promise and seemed to work against ALS in a mid-stage clinical trial in 2011.






Biogen shares fell 6 percent in premarket trading on Thursday.


ALS is a disease of nerve cells in the brain and spinal cord that affects about 30,000 Americans, according to the ALS Association. About 5,600 Americans are diagnosed with the disease each year. American baseball player Henry Louis “Lou” Gehrig died of the disease in 1941.


There is currently only one drug that is used to help people with ALS – Rilutek, or riluzole, made by Sanofi. It has been shown to prolong the life of people with ALS, who have a life expectancy of two to five years after diagnosis.


The news was an uncommon blow for a company that has excelled in recent years and could push shares down about 10 percent, Mark Schoenebaum, a biotech analyst at ISI Group, said in an early research note.


He said analysts had estimated sales for the drug in 2016 of about $ 350 million – or about 4 percent of Biogen revenue.


The late-stage dexpramipexole trial, which was called Empower and enrolled 943 people with ALS at 81 sites in 11 countries, did not show that the drug increased the ability of people with the disease to function or improved their survival rates.


“We share the disappointment of members of the ALS community, who had hoped that dexpramipexole would offer a meaningful new treatment option,” Biogen Executive Vice President of Research and Development Douglas Williams said in a statement.


The company said it would continue to work on potential treatments for the disease.


(Reporting by Caroline Humer in New York and Esha Dey in Bangalore; Editing by Roshni Menon, Nick Zieminski and John Wallace)


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Women Lose Half Their Weight: How They Did It






At 25 years old and 288 pounds, Ashley Donahoo was depressed.


“I was unhappy with my job, I was unhappy with the direction my life was going, and I had a hard time enjoying the little things that my kids wanted to do,” the 27-year-old mother of two from Pace, Fla., said. “My health was failing. My doctor told me that he didn’t think I was going to make it to 30 if I kept on [this way]. … It kept getting worse and worse.”






Donahoo was concerned, but it was her faithful husband, David, who pushed her on a path to health, starting with a walk around the block.


“His heart was breaking for me,” she said. “And he saw how unhappy I was, and he came to me and said, ‘We’re going to go for a walk.’  And I was, like, ‘No, we’re not.’”


Her husband won that battle, and on the walk, she started thinking about her own choices and future.


“The realization hit me that I made this choice.  I made this choice to get where I am right now.  So I’m going to start making a different choice,” she said.   ”I put my health and myself on back burner, and I think … it had all caught up to me.”


Jumpstart Your Weight Loss: CLICK HERE to Ask a Celebrity Trainer a Question!


Like Donahoo, Caroline Jhingory reached a similar eye-opening realization about her weight.


“I looked in the mirror one day and just realized I didn’t recognize the person that was staring back at me,” said Jhingory, 32, of Washington, D.C.


Jhingory’s struggles with her weight began early. At age 8, she weighed 120 pounds. Taunted by her peers, Jhingory was enrolled in a medical weight loss program, but it didn’t work because she would sneak junk food like candy bars.


“I found a way to be a food hustler and get whatever food I wanted,” she said. “Not only did I spend two decades of my life morbidly obese. I spent two decades of my life being taunted and teased in every environment. I never went to prom. I never had dates. I couldn’t ride a roller coaster because the safety bar wouldn’t go over my stomach.”


Jhingory remained heavy until college, when she tipped the scales at 303 pounds and started feeling self-conscious in her new environment.


“I felt like I had a moment when all these difficult experiences were a huge pause button on my life. I finally said to myself, ‘I’m tired of this. I want to have a normal life.’”


Jhingory started walking everywhere. Then, she took up a daily cardio regimen to shed the weight, and she rid her pantry of tempting snack foods she once binged on. Now 149 pounds, she has reclaimed her shape and kept off the weight.


Jhingory’s amazing transformation, along with Donahoo’s and other weight-loss success stories, were spotlighted in the “Half Their Size” feature in the latest issue of People magazine.


RELATED: Is Being Overweight Really Bad For You?


Donahoo cut out the late-night binges that brought her down and, thanks to her strong support system, lost 137 pounds. She credited her weight loss success to tracking her food and exercise on livestrong.com and running. She has run two 5Ks.


Leah Fernandez of Atlanta found herself at 251 pounds after two pregnancies. The baby weight stuck and she tended to eat emotionally.


“I wanted the food,” she said. “It made me feel good, and so I ate it.”


But it was the motivation to be there for her children that helped her turn it all around.


“Thinking about going out to the park with my kids felt like work to me, you know?  And at some point I realized that’s ridiculous. Not only am I cheating myself but I’m cheating my kids of me,” she said.


Fernandez turned to Jenny Craig in March 2011 and hasn’t looked back. Since then, she has lost half her weight by staying active with her kids and incorporating walking into her lifestyle.


“I’m getting my groove back.  Leah’s getting her groove back,” she said.


RELATED: Apps to Help With Weight-Loss Resolutions


RELATED: 329 Pound-Weight-Loss Trio Share Their Secrets


READ MORE: 138 Pound Weight Loss Changes Woman’s Life


Health News Headlines – Yahoo! News





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Women Lose Half Their Weight: How They Did It






At 25 years old and 288 pounds, Ashley Donahoo was depressed.


“I was unhappy with my job, I was unhappy with the direction my life was going, and I had a hard time enjoying the little things that my kids wanted to do,” the 27-year-old mother of two from Pace, Fla., said. “My health was failing. My doctor told me that he didn’t think I was going to make it to 30 if I kept on [this way]. … It kept getting worse and worse.”






Donahoo was concerned, but it was her faithful husband, David, who pushed her on a path to health, starting with a walk around the block.


“His heart was breaking for me,” she said. “And he saw how unhappy I was, and he came to me and said, ‘We’re going to go for a walk.’  And I was, like, ‘No, we’re not.’”


Her husband won that battle, and on the walk, she started thinking about her own choices and future.


“The realization hit me that I made this choice.  I made this choice to get where I am right now.  So I’m going to start making a different choice,” she said.   ”I put my health and myself on back burner, and I think … it had all caught up to me.”


Jumpstart Your Weight Loss: CLICK HERE to Ask a Celebrity Trainer a Question!


Like Donahoo, Caroline Jhingory reached a similar eye-opening realization about her weight.


“I looked in the mirror one day and just realized I didn’t recognize the person that was staring back at me,” said Jhingory, 32, of Washington, D.C.


Jhingory’s struggles with her weight began early. At age 8, she weighed 120 pounds. Taunted by her peers, Jhingory was enrolled in a medical weight loss program, but it didn’t work because she would sneak junk food like candy bars.


“I found a way to be a food hustler and get whatever food I wanted,” she said. “Not only did I spend two decades of my life morbidly obese. I spent two decades of my life being taunted and teased in every environment. I never went to prom. I never had dates. I couldn’t ride a roller coaster because the safety bar wouldn’t go over my stomach.”


Jhingory remained heavy until college, when she tipped the scales at 303 pounds and started feeling self-conscious in her new environment.


“I felt like I had a moment when all these difficult experiences were a huge pause button on my life. I finally said to myself, ‘I’m tired of this. I want to have a normal life.’”


Jhingory started walking everywhere. Then, she took up a daily cardio regimen to shed the weight, and she rid her pantry of tempting snack foods she once binged on. Now 149 pounds, she has reclaimed her shape and kept off the weight.


Jhingory’s amazing transformation, along with Donahoo’s and other weight-loss success stories, were spotlighted in the “Half Their Size” feature in the latest issue of People magazine.


RELATED: Is Being Overweight Really Bad For You?


Donahoo cut out the late-night binges that brought her down and, thanks to her strong support system, lost 137 pounds. She credited her weight loss success to tracking her food and exercise on livestrong.com and running. She has run two 5Ks.


Leah Fernandez of Atlanta found herself at 251 pounds after two pregnancies. The baby weight stuck and she tended to eat emotionally.


“I wanted the food,” she said. “It made me feel good, and so I ate it.”


But it was the motivation to be there for her children that helped her turn it all around.


“Thinking about going out to the park with my kids felt like work to me, you know?  And at some point I realized that’s ridiculous. Not only am I cheating myself but I’m cheating my kids of me,” she said.


Fernandez turned to Jenny Craig in March 2011 and hasn’t looked back. Since then, she has lost half her weight by staying active with her kids and incorporating walking into her lifestyle.


“I’m getting my groove back.  Leah’s getting her groove back,” she said.


RELATED: Apps to Help With Weight-Loss Resolutions


RELATED: 329 Pound-Weight-Loss Trio Share Their Secrets


READ MORE: 138 Pound Weight Loss Changes Woman’s Life


Health News Headlines – Yahoo! News





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Could Trip to Mars Cause Alzheimer’s?






Space travel has always been portrayed as risky — no air or water, extreme temperatures — a place where even a small miscalculation can be fatal. It can also be hazardous to your brain health, particularly on a three-year-long mission to Mars, according to a study published this week in the scientific journal PLOS ONE.


The eight-year long study, conducted at the NASA Space Radiation Laboratory at Brookhaven National Laboratory on New York’s Long Island, found that the cosmic radiation on such a mission could accelerate the onset of Alzheimer’s disease.






NASA is working on sending astronauts to a passing asteroid in the 2020s, and talks of a trip to Mars in the 2030s. It would take three years, with current technology, to get there and back. Current spacecraft are not heavily shielded from the cosmic radiation crew members would encounter beyond Earth’s protective magnetic field.


Researchers used mice that were genetically engineered to be predisposed to Alzheimer’s disease. They exposed them to cosmic radiation that was simulated in the lab.


“Galactic cosmic radiation poses a significant threat to future astronauts,” said Dr. M. Kerry O’Banion, senior author and professor of neurobiology and anatomy at the University of Rochester Medical Center.


The study team wanted to see if radiation had the potential to accelerate Alzheimer’s in those who were genetically vulnerable. Mouse models have been used extensively in this type of research and the rate at which they develop the disease is well understood.


Scientists have long worried about the potential dangers of working and living in deep space. Cosmic radiation beyond low Earth orbit, researchers say, could lead to cancer, cardiovascular disease, even cataracts.


Radiation exposure can cause acute effects such as nausea, vomiting, fatigue, skin injury and changes to white blood cell counts and the immune system, according to the National Space Biomedical Research Institute. Longer-term radiation effects include damage to the eyes, gastrointestinal system, lungs and central nervous system.


On Earth, humans are protected by the planet’s atmosphere and magnetic field. Crew members on the International Space Station, at an altitude of 200 miles, are still within the magnetic sheath that surrounds us. The 24 Apollo astronauts who flew to the moon between 1969 and 1972 were not protected, but the longest missions lasted less than two weeks.


Once out of low orbit, astronauts are exposed to showers of different radioactive particles. Though engineers say they can protect themselves from the radiation associated with solar flares, so far, they cannot block other forms of cosmic radiation.


The longer astronauts are in deep space, the greater the exposure to this low-level radiation.


This is the first such study to explore effects of radiation on the nervous system, a phenomenon known as neurodegeneration, according to the authors.


“The possibility that radiation exposure in space may give rise to health problems such as cancer has long been recognized,” said O’Banion. “However, this study shows for the first time that exposure to radiation levels equivalent to a mission to Mars could produce cognitive problems and speed up changes in the brain that are associated with Alzheimer’s disease.”


O’Banion has spent the last 20 years studying Alzheimer’s disease.


He and his fellow researchers studied a form of radiation from so-called high-mass, high-charged particles, which come in various forms and fly through space at high speeds. Some come from distant stars that have exploded.


At Brookhaven, where a portion of the research was conducted, particle accelerators were able to recreate some of the radioactive particles found in space.


“It is extremely difficult from an engineering perspective to effectively shield against them,” said O’Banion. “One would have to essentially wrap a spacecraft in a six-foot block of lead or concrete.”


For the study, researchers used mice that had been engineered to have two human gene mutations associated with familial Alzheimer’s.


“Essentially, they were healthy mice with nasty genes,” said O’Banion. Under natural conditions, mice do not get the disease.


The mice were exposed to the radiation for several minutes. Six months later, researchers evaluated the exposure to see if it had any effect.


“A minute or two [of exposure] is like three years in human life,” O’Banion said. “It’s apples and oranges, a very different kind of exposure, but the total dose is equivalent to what an astronaut would receive [on a three-year Mars mission].”


Cosmic radiation is unlike anything on earth, according to O’Banion, similar only to what might be experienced in a nuclear accident.


“The big problem NASA faces is that shielding is not effective, and a spacecraft is not bulky enough to protect them over long periods of travel,” said O’Banion. “At least not now. In scenarios I have heard of sending people to Mars, they would then build an underground shelter on a long-term mission in order to protect them from radiation.”


While the research does not solve the problem of radiation in space or explain why humans develop Alzheimer’s disease, it is important, according to O’Banion.


“My own bias is this,” he said. “It’s just another example of how the environment can influence diseases. The mice had a genetic predisposition and you have added an environmental injury — an insult to their system. And now they show exacerbation of the disease.”


There may even be parallels with the development of the disease after brain injuries in football players, he said.


Jeff Chancellor, a scientist in radiation physics at the National Space Biomedical Research Institute, said the Rochester team’s study is solid.


“I know most of the authors and they are very well respected, and I have full confidence in their results,” he said. . “The main benefit of their research is being able to further enhance the field and perhaps provide justification for more research.”


“Any time you identify a mechanism for how a disease or a condition is induced, you further the ability to mitigate it,” he said. “It provides more tools for the researchers and for M.D.s … There are great benefits to all these studies.”


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Clinton receiving blood thinners to dissolve clot






WASHINGTON (AP) — Doctors treating Secretary of State Hillary Rodham Clinton for a blood clot in her head said blood thinners are being used to dissolve the clot and they are confident she will make a full recovery.


Clinton didn’t suffer a stroke or neurological damage from the clot that formed after she suffered a concussion during a fainting spell at her home in early December, doctors said in a statement Monday.






Clinton, 65, was admitted to New York-Presbyterian Hospital on Sunday when the clot turned up on a follow-up exam on the concussion, Clinton spokesman Phillipe Reines said.


The clot is located in the vein in the space between the brain and the skull behind the right ear. She will be released once the medication dose for the blood thinners has been established, the doctors said.


In their statement, Dr. Lisa Bardack of the Mount Kisco Medical Group and Dr. Gigi El-Bayoumi of George Washington University said Clinton was making excellent progress and was in good spirits.


Clinton’s complication “certainly isn’t the most common thing to happen after a concussion” and is one of the few types of blood clots in the skull or head that are treated with blood thinners, said Dr. Larry Goldstein, a neurologist who is director of Duke University’s stroke center. He is not involved in Clinton’s care.


The area where Clinton’s clot developed is “a drainage channel, the equivalent of a big vein inside the skull. It’s how the blood gets back to the heart,” Goldstein said.


Blood thinners usually are enough to treat the clot and it should have no long-term consequences if her doctors are saying she has suffered no neurological damage from it, Goldstein said.


Clinton returned to the U.S. from a trip to Europe, then fell ill with a stomach virus in early December that left her severely dehydrated and forced her to cancel a trip to North Africa and the Middle East. Until then, she had canceled only two scheduled overseas trips, one to Europe after breaking her elbow in June 2009 and one to Asia after the February 2010 earthquake in Haiti.


Her condition worsened when she fainted, fell and suffered a concussion while at home alone in mid-December as she recovered from the virus. It was announced Dec. 13.


This isn’t the first time Clinton has suffered a blood clot. In 1998, midway through her husband’s second term as president, Clinton was in New York fundraising for the midterm elections when a swollen right foot led her doctor to diagnose a clot in her knee requiring immediate treatment.


Clinton had planned to step down as secretary of state at the beginning of President Barack Obama’s second term. Whether she will return to work before she resigns remained a question.


Democrats are privately if not publicly speculating: How might her illness affect a decision about running for president in 2016?


After decades in politics, Clinton says she plans to spend the next year resting. She has long insisted she had no intention of mounting a second campaign for the White House four years from now. But the door is not entirely closed, and she would almost certainly emerge as the Democrat to beat if she decided to give in to calls by Democratic fans and run again.


Her age — and thereby health — would probably be a factor under consideration, given that Clinton would be 69 when sworn in, if she were elected in 2016. That might become even more of an issue in the early jockeying for 2016 if what started as a bad stomach bug becomes a prolonged, public bout with more serious infirmity.


Not that Democrats are willing to talk openly about the political implications of a long illness, choosing to keep any discussions about her condition behind closed doors. Publicly, Democrats reject the notion that a blood clot could hinder her political prospects.


“Some of those concerns could be borderline sexist,” said Basil Smikle, a Democratic strategist who worked for Clinton when she was a senator. “Dick Cheney had significant heart problems when he was vice president, and people joked about it. He took the time he needed to get better, and it wasn’t a problem.”


It isn’t uncommon for presidential candidates’ health — and age — to be an issue. Both in 2000 and 2008, Sen. John McCain, R-Ariz., had to rebut concerns he was too old to be commander in chief or that his skin cancer could resurface.


Two decades after Clinton became the first lady, signs of her popularity — and her political strength — are ubiquitous.


Obama had barely declared victory in November when Democrats started zealously plugging Clinton as their strongest White House contender four years from now, should she choose to take that leap.


“Wouldn’t that be exciting?” House Democratic leader Nancy Pelosi declared in December. “I hope she goes. Why wouldn’t she?”


Even Republicans concede that were she to run, Clinton would be a force to be reckoned with.


“Trying to win that will be truly the Super Bowl,” Newt Gingrich, the former House Speaker and 2012 GOP presidential candidate, said in December. “The Republican Party today is incapable of competing at that level.”


Americans admire Clinton more than any other woman in the world, according to a Gallup poll released Monday — the 17th time in 20 years that Clinton has claimed that title. And a recent ABC News/Washington Post poll found that 57 percent of Americans would support Clinton as a candidate for president in 2016, with just 37 percent opposed. Websites have already cropped up hawking “Clinton 2016″ mugs and tote bags.


Beyond talk of future politics, Clinton’s three-week absence from the State Department has raised eyebrows among some conservative commentators who questioned the seriousness of her ailment after she canceled planned Dec. 20 testimony before Congress on the deadly attack on the U.S. diplomatic mission in Benghazi, Libya.


Clinton had been due to discuss with lawmakers a scathing report she had commissioned on the attack. It found serious failures of leadership and management in two State Department bureaus were to blame for insufficient security at the facility. Clinton took responsibility for the incident before the report was released, but she was not blamed. Four officials cited in the report have either resigned or been reassigned.


___


Associated Press writer Ken Thomas in Washington and AP Chief Medical Writer Marilynn Marchione in Milwaukee contributed to this report.


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La terapia prostática con protones no provoca menos efectos adversos






NUEVA YORK (Reuters Health) – Un costoso tratamiento para el


cáncer de próstata, conocido como terapia con haz de protones,






provoca tantos efectos adversos como las radioterapias más


comunes y económicas.


“En el largo plazo, realmente no existen diferencias entre


los resultados de la terapia con protones y la radioterapia de


intensidad modulada (IMRT, por su sigla en inglés) en los


hombres con cáncer prostático”, dijo el autor principal del


estudio, el doctor James Yu, radiólogo y oncólogo de la Facultad


de Medicina de la Universidad de Yale.


Los defensores de la terapia con protones sostienen que el


haz de protones irradia directamente al tumor y, así, evita los


efectos adversos. La IMRT, que es más común, deja expuestos a la


radiación a tejidos sanos, lo que para los investigadores


aumentaría los efectos adversos y el riesgo de nuevos tumores.


Pero, en un año, los autores del nuevo estudio hallaron la


misma cantidad de efectos adversos en pacientes tratados con


ambos métodos.


El cáncer de próstata es el cáncer masculino más común; cada


año, causa 28.000 muertes en Estados Unidos. Aun así, muchos


hombres mueren por otras causas porque este cáncer avanza


lentamente. Los tratamientos incluyen la quimioterapia, la


hormonoterapia, la cirugía y la espera vigilada.


Aunque los investigadores aún debaten cuál de los dos


tratamientos (haz de protones e IMRT) son la mejor opción para


los pacientes que optan por la radioterapia, eso no impidió que


proliferaran los centros que ofrecen la terapia con protones. La


Asociación Nacional de Terapia con Protones estima que en


Estados Unidos existen 10 centros y ocho en desarrollo o


construcción.


Cada centro cuesta más de 125 millones de dólares y Medicare


reintegra el doble de eso a cambio de sus servicios.


En el estudio publicado en Journal of the National Cancer


Institute, los autores revisaron los reintegros de Medicare del


2008 y el 2009 debido a complicaciones asociadas con el


tratamiento en casi 28.000 hombres con cáncer de próstata desde


hacía un año. Sólo el 2 por ciento de esos pacientes había


recibido terapia con protones; el resto, IMRT.


A los seis meses, casi el 10 por ciento de los pacientes


tratados con IMRT y el 6 por ciento de aquellos tratados con haz


de protones tuvieron efectos adversos, como incontinencia,


sensación de quemazón al orinar o problemas de erección.


Y las diferencias desaparecieron al año del tratamiento,


cuando casi uno de cada cinco pacientes padecía efectos adversos


independientemente del tratamiento recibido.


El equipo de Yu determinó que la terapia con protones cuesta


dos veces más que la IMRT: 32.428 dólares por ronda, versus


18.575 dólares, algo que coincide con estudios previos.


“Ahora, son los defensores de la terapia con protones los


que deberían probar los beneficios”, dijo Yu.


Los autores se concentraron en los efectos adversos, no en


comparar la efectividad de los tratamientos, lo que para los


promotores del uso del haz de protones es una gran debilidad.


FUENTE: Journal of the National Cancer Institute, online 14


de diciembre del 2012.


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Vomiting Larry battles “Ferrari of the virus world”






LONDON (Reuters) – Poor Larry isn’t looking too good. He’s pale and clammy and he’s been projectile vomiting over and over again while his carers just stand by and watch.


Yet their lack of concern for Larry is made up for by their intense interest in how far splashes of his vomit can fly, and how effectively they evade attempts to clean them up.






Larry is a “humanoid simulated vomiting system” designed to help scientists analyze contagion. And like millions around the world right now, he’s struggling with norovirus – a disease one British expert describes as “the Ferrari of the virus world”.


“Norovirus is one of the most infectious viruses of man,” said Ian Goodfellow, a professor of virology at the department of pathology at Britain‘s University of Cambridge, who has been studying noroviruses for 10 years.


“It takes fewer than 20 virus particles to infect someone. So each droplet of vomit or gram of feces from an infected person can contain enough virus to infect more than 100,000 people.”


Norovirus is hitting hard this year – and earlier too.


In Britain so far this season, more than a million people are thought to have suffered the violent vomiting and diarrhea it can bring. The Health Protection Agency (HPA) said this high rate of infection relatively early in the winter mirrors trends seen in Japan and Europe.


“In Australia the norovirus season also peaks during the winter, but this season it has gone on longer than usual and they are seeing cases into their summer,” it said in a statement.


In the United States, the Centers for Disease Control and Prevention (CDC) say norovirus causes 21 million illnesses annually. Of those who get the virus, some 70,000 require hospitalization and around 800 die each year.


PROFUSE AND PROJECTILE


Norovirus dates back more than 40 years and takes its name from the U.S. city of Norwalk, Ohio, where there was an outbreak of acute gastroenteritis in school children in November 1968.


Symptoms include a sudden onset of vomiting, which can be projectile, and diarrhea, which may be profuse and watery. Some victims also suffer fevers, headaches and stomach cramps.


John Harris, an expert on the virus at Britain’s HPA, puts it simply: “Norovirus is very contagious and very unpleasant.”


What makes this such a formidable enemy is its ability to evade death from cleaning and to survive long periods outside a human host. Scientists have found norovirus can remain alive and well for 12 hours on hard surfaces and up to 12 days on contaminated fabrics such as carpets and upholstery. In still water, it can survive for months, maybe even years.


At the Health and Safety Laboratory in Derbyshire, northern England, where researcher Catherine Makison developed the humanoid simulated vomiting system and nicknamed him “Vomiting Larry”, scientists analyzing his reach found that small droplets of sick can spread over three meters.


“The dramatic nature of the vomiting episodes produces a lot of aerosolized vomit, much of which is invisible to the naked eye,” Goodfellow told Reuters.


Larry’s projections were easy to spot because he had been primed with a “vomitus substitute”, scientists explain, which included a fluorescent marker to help distinguish even small splashes – but they would not be at all easily visible under standard white hospital lighting.


Add the fact that norovirus is particularly resistant to normal household disinfectants and even alcohol hand gels, and it’s little wonder the sickness wreaks such havoc in hospitals, schools, nursing homes, cruise ships and hotels.


During the two weeks up to December 23, there were 70 hospital outbreaks of norovirus reported in Britain, and last week a cruise ship that sails between New York and Britain’s Southampton docked in the Caribbean with about 200 people on board suffering suspected norovirus.


MOVING TARGET


The good news, for some, is that not everyone appears to be equally susceptible to norovirus infection. According to Goodfellow, around 20 percent of Europeans have a mutation in a gene called FUT2 that makes them resistant.


For the rest the only likely good news will have to wait for the results of trials of a potential norovirus vaccine developed by U.S. drugmaker LigoCyte Pharmaceuticals Inc, or from one of several research teams around the world working on possible new antiviral drugs to treat the infection.


Early tests in 2011 indicated that around half of people vaccinated with the experimental shot, now owned by Japan’s Takeda Pharmaceutical Co, were protected from symptomatic norovirus infection.


The bad news, virologists say, is that the virus changes constantly, making it a moving target for drug developers. There is also evidence that humans’ immune response to infection is short-lived, so people can become re-infected by the same virus within just a year or two.


“There are many strains, and the virus changes very rapidly – it undergoes something virologists call genetic drift,” Harris said in a telephone interview. “When it makes copies of itself, it makes mistakes in those copies – so each time you encounter the virus you may be encountering a slightly different one.”


This means that even if a vaccine were to be fully developed – still a big ‘if’ – it would probably need to be tweaked and repeated in a slightly different formula each year to prevent people getting sick.


Until any effective drugs or vaccines are developed, experts reckon that like the common cold, norovirus will be an unwelcome guest for many winters to come. Their advice is to stay away from anyone with the virus, and use soap and water liberally.


“One of the reasons norovirus spreads so fast is that the majority of people don’t wash their hands for long enough,” said Goodfellow. “We’d suggest people count to 15 while washing their hands and ensure their hands are dried completely.”


(Reporting by Kate Kelland; Editing by Will Waterman)


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Republican Senator: chances for “fiscal cliff” deal “exceedingly good”






WASHINGTON (Reuters) – Republican Senator Lindsey Graham said on Sunday that chances for a small “fiscal Cliff” deal in the next 48 hours were “exceedingly good” and that President Barack Obama had won.


“I think people don’t want to go over the cliff if we can avoid it,” Graham said on Fox News Sunday.






“This deal won’t affect the debt situation, it will be a political victory for the president and I hope we’ll have the courage of our convictions when it comes time to raise the debt ceiling to fight for what we believe as Republicans, but hats off to the president, he won,” Graham said.


(Reporting By Tabassum Zakaria; Editing by David Brunnstrom)


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Obama says failure to reach fiscal deal would hurt markets






WASHINGTON (Reuters) – Financial markets would be affected adversely if U.S. lawmakers fail to agree on a “fiscal cliff” deal before Tuesday, President Barack Obama said in an interview broadcast on Sunday, while urging Congress to act quickly to extend tax cuts for middle-class Americans.


Lawmakers are seeking a last-minute deal that would set aside $ 600 billion in tax increases and across-the-board government spending cuts that are set to start within days. If Congress does not make that happen, the first bill brought up in the new year would be to reduce taxes for middle-income families, Obama told NBC’s “Meet the Press.”






“Now I think that over the next 48 hours, my hope is that people recognize that, regardless of partisan differences, our top priority has to be to make sure that taxes on middle-class families do not go up. That would hurt our economy badly,” Obama said in the interview taped on Saturday.


“We can get that done. Democrats and Republicans both say they don’t want taxes to go up on middle-class families. That’s something we all agree on. If we can get that done, that takes a big bite out of the ‘fiscal cliff.’ It avoids the worst outcomes,” Obama added.


Low income tax rates first put in place under Republican former President George W. Bush are due to expire at the end of the day on Monday – the last day of 2012.


Obama said that failing to reach a deal would have a negative impact on financial markets.


“If people start seeing that on January 1st this problem still hasn’t been solved, that we haven’t seen the kind of deficit reduction that we could have had had the Republicans been willing to take the deal that I gave them … then obviously that’s going to have an adverse reaction in the markets,” he said.


RARE SENATE SESSION ON SUNDAY


Obama met with congressional leaders at the White House on Friday and declared himself cautiously optimistic about the chances of an agreement, but he noted in the interview that nothing had materialized since then.


“I was modestly optimistic yesterday, but we don’t yet see an agreement. And now the pressure’s on Congress to produce,” he said.


The Senate is scheduled to hold a rare Sunday session beginning at 1 p.m. EST (1800 GMT), but it was not clear whether the chamber would have fiscal-cliff legislation to act upon.


Obama sketched out what he believed to be the most likely scenarios the end the back-and-forth between both sides. Either the congressional leaders would come up with a deal, or Democrats in the Senate would bring a bill to the floor seeking an up-or-down vote to extend tax cuts for middle income earners.


“And if all else fails, if Republicans do in fact decide to block it, so that taxes on middle class families do in fact go up on January 1st, then we’ll come back with a new Congress on January 4th and the first bill that will be introduced on the floor will be to cut taxes on middle class families,” he said.


Obama chided Republicans for resisting his call for tax rates to go up for the top two percent of U.S. earners despite what he viewed as significant compromises on his part to cut spending and reform expensive social programs for the poor and elderly.


“They say that their biggest priority is making sure that we deal with the deficit in a serious way, but the way they’re behaving is that their only priority is making sure that tax breaks for the wealthiest Americans are protected. That seems to be their only overriding, unifying theme,” Obama said.


“The offers that I’ve made to them have been so fair that a lot of Democrats get mad at me. I mean I offered to make some significant changes to our entitlement programs in order to reduce the deficit,” he said.


(Reporting by Jeff Mason; Editing by David Brunnstrom)


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MSF warns Kenya not to send more refugees to stricken camp






LONDON (Reuters) – Conditions in a camp for Somali refugees in Kenya are deplorable and a government plan to send in thousands more would pose a major risk to health, medical charity Medecins Sans Frontieres (MSF) said on Friday.


Kenya has more than half a million refugees from Somalia, which has lacked an effective central government since the outbreak of civil war in 1991.






A series of bombings, shootings and hand-grenade attacks blamed on Somali militants prompted the government on December 18 to stop registering asylum seekers and refugees in urban areas.


A Kenyan official said more than 100,000 refugees must now head to the remote Dadaab camp in the country’s remote north. Amnesty International said the order breached international law.


Dadaab camp was set up 20 years ago and already houses four times the population it was built for. Hunger and disease outbreaks are common.


MSF says its inhabitants suffer from overcrowding and poor sanitation that recent floods had worsened.


“The assistance provided here in Dadaab is already completely overstretched and is not meeting the current needs,” said Elena Velilla, MSF’s head of mission in Kenya.


In the last month, the number of children admitted to Dadaab’s hospital for severe acute malnutrition has doubled to around 300, MSF said. Sixty-three of those were taken to intensive care this week after developing serious complications.


Most of the sick are also suffering from acute watery diarrhea or severe respiratory tract infections, MSF said.


(Reporting by Kate Kelland; Editing by Tom Pfeiffer)


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‘Frankenfish’ Nears FDA Approval as Debate Heats up






Genetically engineered salmon could make its way onto plates in the new year, but your body won’t notice anything fishy about the filet, experts say.


The Food and Drug Administration has determined genetically engineered salmon won’t threaten the environment, clearing it of all but one final hurdle before it shows up on shelves throughout the nation — and igniting a final 60-day debate on whether it poses health risks before it’s officially approved.






Although it’s been nicknamed “Frankenfish” by critics, health professionals say they aren’t worried the lab-engineered salmon will cause more allergies or other harmful effects than any other breed of fish.


“The hard science part is that we have been creating [animals] using genes and natural selection for years to genetically predict what kinds of food animals, and recreational animals and such we have on our planet,” said Dr. William Schaffner, chairman of preventive medicine at Vanderbilt University Medical Center in Nashville, Tenn.


He cited thoroughbred horses, show dogs and crops as examples of genetically engineered plants and animals dating back centuries.


“When Farmer Jones did it in his cornfield to try to get a better crop, it didn’t bother people,” Schaffner said. “When scientist Jones did the same thing in a much more sophisticated fashion in a lab, that does bother people.”




Superfish: DNA-Altered Salmon Coming to Your Dinner Plate? Watch Video





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A biotech company in Massachusetts called AquaBounty created the AquaAdvantage salmon, which is really an Atlantic salmon with an added Pacific salmon gene to make it grow faster and an added eel gene to make it grow year-round.


The end result is a fish that tastes like an Atlantic salmon but grows twice as fast, making it cheaper to produce and sell. Because the FDA likely won’t require a label that says the salmon was genetically modified, consumers won’t know the difference.


Click here to read about ABC News’ exclusive look at the AquaBounty facility.


Schaffner thinks genetically engineered food is one way to help solve world hunger and, as long as the FDA thoroughly reviews it, there shouldn’t be a problem.


But Rep. Dennis Kucinich, D-Ohio, said he’s been disappointed with FDA decisions on genetically modified food since 1992, when the FDA determined it is equivalent to any other food. He said there’s not enough science to allow AquaAdvantage onto our dinner plates, but the biotech industry has had so much influence in Congress that it’s been impossible to stop.


“Now this latest action by the FDA somehow determined that the salmon is safe — safe for who?” he asked. “Safe for the investors?”


Kucinich has introduced legislation related to genetically modified food and labeling in every Congress since 1997, but it has never passed. He said Monsanto, the $ 2 billion company that produces genetically modified seed and pesticides, is partially to blame because it has so much money and influence.


AquaBounty, the biotech firm that makes AquaAdvantage, contributed less than $ 150,000 toward lobbying Congress over the last three years, according to campaign finance records available on OpenSecrets.org. In contrast, Monsanto spent more than $ 19 million lobbying over the same time frame.


Kucinich said the AquaAdvantage issue is a complex one, and worries about whether the genetically altered fish will hurt naturally occurring wild fish populations by overfeeding because they grow twice as fast as their naturally occurring relatives. However, the most recent FDA finding showed that this is not a concern because the fish are mostly sterile and not expected to escape their man-made farms.


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Obama heads back to Washington as “cliff” deadline nears






WASHINGTON (Reuters) – President Barack Obama was flying back to Washington on Thursday and the top Republican in Congress planned to speak with House of Representatives lawmakers as the clock ticked toward a year-end deadline for action to avert the looming “fiscal cliff” tax hikes and spending cuts.


Markets around the world awaited action in Washington to prevent tax hikes on nearly all Americans and the deep automatic government spending cuts due to kick in at the beginning of next month that could push the U.S. economy back into recession.






Such action, however, remained far from certain, with Republicans and Democrats each insisting the other side move first amid continuing partisan gridlock.


Air Force One carrying Obama from Hawaii took off at about 3 a.m. EST for a journey that can take nearly half a day.


The U.S. Senate was scheduled to meet later on Thursday but on matters unrelated to the “fiscal cliff.” The Democrats control the Senate and the Republicans control the House.


Senate Majority Leader Harry Reid on Wednesday said through a spokesman that the Senate was ready to consider any bills coming from the House but would take no action on its own.


Speaker John Boehner and other House Republican leaders, who said on Wednesday they were willing to take up a “fiscal cliff” measure only after the Senate acts on one, planned a conference call with Republican House members on Thursday.


The expectation for the call was that lawmakers would be told to get back to Washington within 48 hours to consider anything the Senate might pass.


Weather permitting, that would bring them to Washington with perhaps three days left before the deadline for action. Storms affecting the Midwest, the South and the Northeast played havoc with airline schedules.


“This isn’t a one party or one house problem. This is (that) leaders in both parties in all branches of the government are not willing to make the deal that they know they have to make. Everybody wants their stuff but doesn’t want to give up what they don’t want to give up,” Republican U.S. Representative Steven LaTourette told CNN on Thursday.


The House and Senate passed bills months ago reflecting their own sharply divergent positions on the expiring low tax rates, which went into effect during the administration of Republican former President George W. Bush.


‘ALL TOO SLOWLY’


Democrats want to allow the tax cuts to expire on the wealthiest Americans. Republicans want to extend the tax cuts for everyone.


“We’re in an economy now that is fragile – still recovering, all too slowly. These tax cuts must be extended for the middle class. We need to protect the middle class from that huge tax increase,” Democratic Senator Richard Blumenthal told CNN.


While Obama and congressional leaders have said that they are willing to negotiate, no substantive discussions are known to have taken place over the holidays and the gap between them appears to remain.


A senior Obama administration official told reporters traveling with Obama that Republican leaders in Congress should step up to head off the looming tax and spending hit.


Congress has proven that it can act swiftly once an agreement is reached. Hope persisted that Republicans and Democrats might come up with a resolution before New Year’s Day that might at least postpone the impact of the tax hikes and spending cuts while further discussions take place.


On that basis, world shares and the euro edged higher on Thursday.


“There is still hope for a last-minute deal, otherwise we’re in for a correction in January. People have already priced in an agreement. Without it, the market can’t stay at these levels,” a Paris-based trader said.


Another battle is just over the horizon in late January or early February over raising the debt ceiling, which puts a limit on the amount of money the U.S. government can borrow to pay its debts and can be raised only with the approval of Congress.


Republican leaders have said they will insist on more budget cuts as a condition of raising the ceiling. Without any action, the U.S. Treasury said on Wednesday the government is set to reach its $ 16.4 trillion debt ceiling on December 31.


The Treasury Department said in a statement it would begin “extraordinary measures” to buy time. Many analysts believe the government can stave the default date off into late February.


(Additional reporting by Doina Chiacu and Alina Selyukh; Editing by Will Dunham)


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Kenya hospital imprisons new mothers with no money






NAIROBI, Kenya (AP) — The director of the Pumwani Maternity Hospital, located in a hardscrabble neighborhood of downtown Nairobi, freely acknowledges that he detains mothers who can’t pay their bills.


Lazarus Omondi says it’s the only way he can keep his medical center running. Now, a New York-based group filed a lawsuit this month in hopes of forcing Pumwani to stop the practice.






Two mothers who live in a mud-wall and tin-roof slum near the maternity hospital said Pumwani wouldn’t let them leave after delivering their babies. The bills the mothers couldn’t afford were $ 60 and $ 160. Guards with sticks would beat mothers who tried to leave without paying, one of the women said.


Omondi says one solution to the problem would be a national health insurance program.


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Light Therapy Helps Ease Winter Blues






Every October as the clocks are turned back, Jose Balido notices that his mood changes, almost as if his body were going into hibernation.


His limbs are heavy and he has trouble moving around. Simple household chores like loading the dishwasher seem “insurmountable,” he said. But when spring arrives, the lethargy lifts.






“It took me a while to realize what it was,” said Balido, owner of a travel social network site, Tripatini. “I was cranky, short-tempered, depressed, feeling hopeless and having difficulty concentrating.”


Balido, 51, was diagnosed a decade ago with seasonal affective disorder or SAD. The condition affects 62 million Americans, according to Michael Terman, director of the Center for Light Treatment and Biological Rhythms at Columbia University and a leader in the field.


About 5 percent of the population experiences the most severe symptoms of SAD — depression and hopelessness — while another 15 percent have the so-called “winter blues” or “winter doldrums.”


The vast majority never fall into full depression, according to Terman, but “plod through winters with slowness and gloominess that takes effort to hide from others.”


Two decades ago, SAD was identified as a legitimate disorder by the National Institute of Mental Health. Since then, the treatment of choice has been light therapy.


Balido, who lives in Miami, sought help from Terman and now undergoes light therapy. He sits in front of a daylight simulator for a half an hour each morning before 10 a.m.


“Within two or three days, the difference was mind-blowing,” he said.


The standard treatment for SAD is 30 minutes of 10,000-lux, diffused, white fluorescent light, used early in the morning. About half the patients are helped quickly — and when treatment is tailored to a person’s individual wake-sleep cycle, remission can climb to 80 percent, according to Terman.


This year, a utility company in the northern Swedish town of Umea installed ultraviolet lights at 30 bus stops to combat the effects of SAD.


“We wanted to celebrate the fact that all our electricity comes from green sources and we wanted to do this in a way that contributed to the citizens in one way or another,” said Umea Energi marketing chief Anna Norrgard in an email to ABCNews.com.


“As it is very dark where we live this time of year, a lot of us are longing for the daylight,” she said. “A lot of us are also a bit more tired this time of year and I would also say we sleep a little bit more. …We wanted to give the citizens of Umea a little energy boost, to be more alert.”


The town is located about 400 miles north of Stockholm. In December, the sun rises at about 10 a.m. and sets around 2:30 p.m. Some towns north of the Arctic Circle have no daylight for several weeks in the winter.


Geography has a strong influence on the prevalence of SAD symptoms, according to Terman.


“The common wisdom is that it’s worse the farther north you live, because winter days are so much shorter,” he said. “Not so simple.”


Columbia research shows that in North America, the incidence of SAD rises from the southern to the middle states, but levels off and stays bad from about 38 degrees North latitude (near such cities as San Francisco, St. Louis and Washington, D.C.) up through the northernmost states and Canada, according to Terman.


But the problem becomes “more severe” at the western edges of the northern states and provinces.


“This important finding reveals the underlying trigger for relapses into winter depression, since the sun rises an hour more later at the western edge of a zone,” said Terman, whose book, “Chronotherapy,” looks at the phenomenon.


Esther Kane, a clinical counselor from Vancouver, Canada, said her practice is filled with patients as the long days descend on British Columbia.


Seasonal Affective Disorder Hits Hard in Canada


“On the West Coast where we live it’s so rampant, I can’t even tell you how many people have it,” said Kane. “Everyone is feeling it with the gray skies and rain. It’s like nighttime all the time here.”


Doctors there routinely prescribe fish oil and vitamin D, as well as light therapy to balance out the sleep hormone melatonin and “boost” the feel-good hormone serotonin, according to Kane. Many are also on antidepressants.


“A lot of people depend on alcohol and drugs all of a sudden,” she said. “They are stuffing themselves with carbs and their food intake is up. They have depression symptoms — what’s the point of getting out of bed in the morning when they feel no energy and there is dark all over them?”


“Some suffer so bad, they can’t function,” said Kane. “Everyone here who can afford to get away for two weeks in the winter, go to Hawaii.”


Even those who live south of the Mason-Dixon Line in the United States can be affected.


Tina Saratsiotis, who works for a faith-based nonprofit group in Towson, Md., was surprised to develop SAD several years ago.


“I used to be a night person and like the dark. Then something changed,” she said. “By fall when it gets darker and the fatigue and sadness comes and by Christmas, it’s difficult to function.”


“It creeps in slowly — I eat more and have trouble concentrating,” she said. “I am more irritable and weeping, like a prolonged version of PMS. It makes it hard to get things done and to enjoy things.”


Columbia’s Terman said there may be genetic influences in who gets SAD — a vulnerability to depression and to insufficient light exposure.


SAD sufferers say it’s especially hard on their relationships when their winter moods kick in.


“Now, he’s very understanding,” said Saratsiotis, who uses both light therapy and antidepressants to deal with the condition. “But before, when I didn’t feel up to going out, I couldn’t explain not feeling great. People wonder, ‘Why doesn’t she like me?’ and, ‘She’s no fun.’”


But when spring rolls around, so does her old self.


“I love the solstice — thank you, Lord, for the solstice,” she said. “I really need [the medication] now, but I may not in the spring and summer.”


But now, in when the days are their shortest, SAD puts a crimp on the holidays.


“It kills Christmas,” said Saratsiotis. “I sit in the middle of the department store with that particular song about the sleigh bells ringing, and I am sobbing. I burst into tears and think, ‘Just kill that song.’”


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Light Therapy Helps Ease Winter Blues






Every October as the clocks are turned back, Jose Balido notices that his mood changes, almost as if his body were going into hibernation.


His limbs are heavy and he has trouble moving around. Simple household chores like loading the dishwasher seem “insurmountable,” he said. But when spring arrives, the lethargy lifts.






“It took me a while to realize what it was,” said Balido, owner of a travel social network site, Tripatini. “I was cranky, short-tempered, depressed, feeling hopeless and having difficulty concentrating.”


Balido, 51, was diagnosed a decade ago with seasonal affective disorder or SAD. The condition affects 62 million Americans, according to Michael Terman, director of the Center for Light Treatment and Biological Rhythms at Columbia University and a leader in the field.


About 5 percent of the population experiences the most severe symptoms of SAD — depression and hopelessness — while another 15 percent have the so-called “winter blues” or “winter doldrums.”


The vast majority never fall into full depression, according to Terman, but “plod through winters with slowness and gloominess that takes effort to hide from others.”


Two decades ago, SAD was identified as a legitimate disorder by the National Institute of Mental Health. Since then, the treatment of choice has been light therapy.


Balido, who lives in Miami, sought help from Terman and now undergoes light therapy. He sits in front of a daylight simulator for a half an hour each morning before 10 a.m.


“Within two or three days, the difference was mind-blowing,” he said.


The standard treatment for SAD is 30 minutes of 10,000-lux, diffused, white fluorescent light, used early in the morning. About half the patients are helped quickly — and when treatment is tailored to a person’s individual wake-sleep cycle, remission can climb to 80 percent, according to Terman.


This year, a utility company in the northern Swedish town of Umea installed ultraviolet lights at 30 bus stops to combat the effects of SAD.


“We wanted to celebrate the fact that all our electricity comes from green sources and we wanted to do this in a way that contributed to the citizens in one way or another,” said Umea Energi marketing chief Anna Norrgard in an email to ABCNews.com.


“As it is very dark where we live this time of year, a lot of us are longing for the daylight,” she said. “A lot of us are also a bit more tired this time of year and I would also say we sleep a little bit more. …We wanted to give the citizens of Umea a little energy boost, to be more alert.”


The town is located about 400 miles north of Stockholm. In December, the sun rises at about 10 a.m. and sets around 2:30 p.m. Some towns north of the Arctic Circle have no daylight for several weeks in the winter.


Geography has a strong influence on the prevalence of SAD symptoms, according to Terman.


“The common wisdom is that it’s worse the farther north you live, because winter days are so much shorter,” he said. “Not so simple.”


Columbia research shows that in North America, the incidence of SAD rises from the southern to the middle states, but levels off and stays bad from about 38 degrees North latitude (near such cities as San Francisco, St. Louis and Washington, D.C.) up through the northernmost states and Canada, according to Terman.


But the problem becomes “more severe” at the western edges of the northern states and provinces.


“This important finding reveals the underlying trigger for relapses into winter depression, since the sun rises an hour more later at the western edge of a zone,” said Terman, whose book, “Chronotherapy,” looks at the phenomenon.


Esther Kane, a clinical counselor from Vancouver, Canada, said her practice is filled with patients as the long days descend on British Columbia.


Seasonal Affective Disorder Hits Hard in Canada


“On the West Coast where we live it’s so rampant, I can’t even tell you how many people have it,” said Kane. “Everyone is feeling it with the gray skies and rain. It’s like nighttime all the time here.”


Doctors there routinely prescribe fish oil and vitamin D, as well as light therapy to balance out the sleep hormone melatonin and “boost” the feel-good hormone serotonin, according to Kane. Many are also on antidepressants.


“A lot of people depend on alcohol and drugs all of a sudden,” she said. “They are stuffing themselves with carbs and their food intake is up. They have depression symptoms — what’s the point of getting out of bed in the morning when they feel no energy and there is dark all over them?”


“Some suffer so bad, they can’t function,” said Kane. “Everyone here who can afford to get away for two weeks in the winter, go to Hawaii.”


Even those who live south of the Mason-Dixon Line in the United States can be affected.


Tina Saratsiotis, who works for a faith-based nonprofit group in Towson, Md., was surprised to develop SAD several years ago.


“I used to be a night person and like the dark. Then something changed,” she said. “By fall when it gets darker and the fatigue and sadness comes and by Christmas, it’s difficult to function.”


“It creeps in slowly — I eat more and have trouble concentrating,” she said. “I am more irritable and weeping, like a prolonged version of PMS. It makes it hard to get things done and to enjoy things.”


Columbia’s Terman said there may be genetic influences in who gets SAD — a vulnerability to depression and to insufficient light exposure.


SAD sufferers say it’s especially hard on their relationships when their winter moods kick in.


“Now, he’s very understanding,” said Saratsiotis, who uses both light therapy and antidepressants to deal with the condition. “But before, when I didn’t feel up to going out, I couldn’t explain not feeling great. People wonder, ‘Why doesn’t she like me?’ and, ‘She’s no fun.’”


But when spring rolls around, so does her old self.


“I love the solstice — thank you, Lord, for the solstice,” she said. “I really need [the medication] now, but I may not in the spring and summer.”


But now, in when the days are their shortest, SAD puts a crimp on the holidays.


“It kills Christmas,” said Saratsiotis. “I sit in the middle of the department store with that particular song about the sleigh bells ringing, and I am sobbing. I burst into tears and think, ‘Just kill that song.’”


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Ethanol Shot to the Heart Saves Man






A cardiologist in England gained international attention when he used an unconventional procedure — a shot of basic alcohol to the heart — to stop an unusual cardio rhythm in an elderly patient.


Dr. Tom Johnson, who carried out the procedure at the Bristol Heart Institute Hospital in Bristol, England, said Ronald Aldom, 77, was doing “fantastically well” after Johnson and his team used pure ethanol to treat Aldom’s rapid heartbeat, a condition called ventricular tachycardia, or VT, about six weeks ago. VT, which starts in the lower two chambers of the heart — the ventricles — can be life-threatening if it goes untreated.






“He’s got a lot of life to live,” Johnson said.


It may seem like a story lifted out of “Pulp Fiction,” but treating VT with ethanol, though rare, is an accepted method that has been used for years. What was noteworthy about Johnson’s procedure was that he had never used ethanol to treat VT before, nor had it ever been done in that part of the United Kingdom.


“[Aldom] was at a point where he felt he had no other option and was kind of facing death,” Johnson said. “While it sounds like a very barbaric treatment, it was a very rewarding one, [but] very high risk.”


Typically, a radio frequency catheter ablation is the treatment choice for someone with VT. A radio frequency catheter is an electrical probe that is threaded into the heart and uses low-voltage electricity to kill the heart tissue around the area causing the arrhythmia. This prevents the tissue from continuing to produce the abnormal rhythm. 




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But Johnson said his colleagues had already tried that technique on Aldom, who had also previously endured heart attacks, without success — scar tissue that forms after heart attacks can reject the electrical treatment.


“It was complicated by the fact that [Aldom] had severe damage to his heart already,” Johnson said. “It got to the point where this poor man was like, ‘please shut it off and let me die.’”


Ethanol ablation works in the same way in that it also selectively destroys heart tissue, but it is more commonly used to treat hypertrophic cardiomyopathy, a condition in which the heart muscle is thick or “bulky,” Johnson said. While he had used ethanol to treat hypertrophic cardiomyopathy before, to use it on Aldom was a last resort.


“This guy had no other option, which is why we were able to do something we had never done before,” Johnson said.


The first step, Johnson said, was for him and his team to electronically map the heart to find and isolate the tissue that was causing the abnormal rhythm. Once the problem artery was located, Johnson’s team fed a wire into the vein graph and inflated a balloon to block the artery. Through that balloon, Johnson said they injected the ethanol while the patient was under anesthetic, killing off the problem tissue.


Destroying the tissue creates a controlled, “selective” heart attack, which can be painful, Johnson said, but it allows the heartbeat to return to normal. 


Using ethanol can have risky complications, Johnson said, because not only does it kill tissue, it can also kill some of the electrical function of the heart — Aldom was already using a pace maker. Another risk, Johnson said, was that the balloon could shift, killing more tissue than intended. But his procedure came through successfully.


Dr. Richard Page, the chairman of the department of medicine at the University of Wisconsin School of Medicine and Public Health and a past-president of the Heart Rhythm Society in the United States, agreed that using ethanol to treat VT was “not a routine procedure at all.”


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Top 7 Holiday Allergy Triggers







When you wheeze through your fa-la-la’s and your nose rivals Rudolph’s, it’s a little tougher to feel jolly. Although allergies peak in the spring and fall, the holidays may surprise sensitive sufferers with a gift of unexpected triggers, from dusty decorations and potent potpourri to even — say it ain’t so — the Christmas tree.


Here are seven yuletide allergens, and expert tips to help you stay focused on shopping and wrapping, not sneezing and scratching.






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Holiday Allergy Triggers


That’s right — the one and only, the centerpiece of all things Christmas, that perfect fir you found hiding in the lot of freshly-cut trees that’s now twinkling with the lights you spent hours untangling — may be to blame for your stuffy nose, watery eyes and rash-y skin.


“Mold is the biggest problem with live Christmas trees,” says Dr. Marilyn Li, an asthma and allergy specialist with the Los Angeles County + University of Southern California Medical Center. “Often, they are cut in advance and kept in humid environments, promoting spore growth.”


Within just two weeks of bringing a tree into your home, indoor mold counts can increase significantly, according to one study.


Other tree-related allergens: The sap contains terpene and other substances that can irritate skin and mucous membranes; and pollen stuck to the tree may be released inside and lead to reactions, adds Dr. Nathanael S. Horne, clinical assistant professor of medicine at NYU school of Medicine and fellow of the American Academy of Allergy, Asthma & Immunology. What about the artificial versions? They could harbor dust and mold from their time in storage, also triggering allergies.


Prevent it: Slip on gloves and wear long sleeves when handling your fresh tree to avoid the sap coming into contact with your skin. Before schlepping your tree inside, give it a good shake (or a blast with a leaf blower) and spray it down with a garden hose (especially the trunk) to help remove some of the pollen and mold, suggests Horne. Then sit the stump in a bucket of water and let the tree dry for few days on a covered porch or in a garage. For an allergen-free fake tree, give it a good wipe-down before decorating with lights and ornaments.


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Holiday Allergy Triggers


For eleven months out of the year, all your ornaments, lights, and holiday chotchkes sit stored out of sight, collecting dust and maybe developing mold. When the boxes of red, green, and gold goodies come out, the symphony of sneezing, coughing and nose-blowing commences.


Prevent it: Before decking your halls, mantels, windows and trees, wipe down each item thoroughly; when it’s time to repack, store your holiday trimming in airtight containers, and in a dry spot if possible. Also, go easy on the spray snow — you may love the look of frosted windows, but any aerosolized chemical can cause irritant reactions in the eyes, nose or lungs of a sensitive person, says Horne.




Holiday Allergy Triggers


The fact that she makes “Why aren’t you pregnant yet?” the topic of Christmas dinner is enough to make you break out in hives, but the nuts that she baked into her dessert crust could be to blame, too.


If you have food allergies, the holidays in particular are a ripe time for reactions, simply because you’re around so. much. food. The most common food allergens are milk, eggs, soy, fish, shellfish, peanuts, tree nuts, and wheat.


“Of those, peanuts and tree nuts will most often make it into holiday dishes without people knowing, and have the potential to cause severe reactions,” says Horne.


Prevent it: It’s a good idea to let your holiday host know about your food allergies; it’s important to ask about the ingredients in each dish; and it’s very nice to volunteer to bring something that’s safe for you, and shareable with others. But what’s crucial is to be prepared with an epinephrine auto-injector (Epi Pen), an emergency dose of antihistamine, and an inhaler if you have asthma—just in case, adds Li, director of the USC Breathmobile, a pediatric clinic that travels to schools and provides ongoing asthma and allergy care to children. Learn which foods and recipes are unexpected sources of allergens at FoodAllergy.org and AAAAI.org.


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Holiday Allergy Triggers


You raise a glass to your loved ones, your boss and colleagues, friends and neighbors, and even the strangers sitting next to you at a bar. There’s lots of cheers-ing this time of year, but be mindful of what you’re using to toast. Some people may experience mild wheezing or other symptoms from the sulfites in wine, for example, and certain alcoholic concoctions contain major food allergens.


Prevent it: There aren’t good tests for sulfite sensitivity, but your reaction to dried fruit — high in this sulfur-based preservative — could be an indicator, says Horne. Pay attention if you have asthma, as sulfites can trigger symptoms. Maraschino cherries contain small amounts of sulfites, as well. Stick with organic wine for a sulfite-free sip. Other triggers to be aware of: Tree nuts may be found specialty beers, particularly seasonal ales; milk is in Irish crème and white chocolate liqueurs; and egg whites may be used to add froth to specialty drinks.


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Holiday Allergy Triggers


This festive plant is a member of the rubber tree family and contains compounds similar to those found in latex, so stay away if you have a latex allergy. Certain groups of people — such as healthcare workers and people with spina bifida who have had numerous surgeries — are more likely to be allergic to latex, says Li, and one study showed that 40 percent of latex-allergic individuals were also allergic to poinsettias.


Prevent it: If you have a latex allergy, keep the iconic plant out of your house—not only can it give you a rash if you touch it, but inhaling the allergen can lead to serious respiratory problems, like shortness of breath and wheezing.


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Holiday Allergy Triggers


Pine-infused potpourri, dessert-scented candles, cinnamon air sprays — while they will make your house smell like Christmas, they can irritate the nose and throats of allergy-sensitive people.


“Candles in particular are an increasingly recognized source of indoor air pollution,” says Horne. “The same is true for air sprays and other types of air fresheners—they can release many different types of noxious compounds, which can generate adverse reactions in sensitive patients.”


Prevent it: If skipping the scents feels Grinch-like, try making your own potpourri with cinnamon sticks and cloves so you know what’s in the mixture, says Horne. And choose candles made of soy or beeswax, suggests Li. There’s not much smell, but you can still enjoy the warm glow. By the way, fireplaces are an absolute no-no for asthmatic patients — the ash and smoke can trigger an attack, so keep the log unlit.


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Holiday Allergy Triggers


Stress doesn’t cause allergies or asthma by itself, but it can hinder your immune system and be a trigger for asthma attacks, says Horne. Chemicals released by the body during stressful times can cause the muscles around your airways to tighten, making it difficult to breathe.


Prevent it: All the deep breathing in the world probably can’t calm the chaos that comes with the season, but what you can do is make sure you take the steps to stay healthy: Stick to your controller medication regimen and get a flu shot, advises Li.


***


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